Stable Suppression of the R2 Subunit of Ribonucleotide Reductase by R2-targeted Short Interference RNA Sensitizes p53(–/–) HCT-116 Colon Cancer Cells to DNA-damaging Agents and Ribonucleotide Reductase Inhibitors-Reference-Cited by-同舟云学术

Stable Suppression of the R2 Subunit of Ribonucleotide Reductase by R2-targeted Short Interference RNA Sensitizes p53(–/–) HCT-116 Colon Cancer Cells to DNA-damaging Agents and Ribonucleotide Reductase Inhibitors

Published:2004-06 Issue:26 Volume:279 Page:27030-27038
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Lin Z. Ping,Belcourt Michael F.,Cory Joseph G.,Sartorelli Alan C.

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference43 articles.

1. Reduction of Ribonucleotides

2. Deoxyribonucleoside triphosphate levels: A critical factor in the maintenance of genetic stability

3. Cell cycle-dependent regulation of mammalian ribonucleotide reductase. The S phase-correlated increase in subunit M2 is regulated by de novo protein synthesis.

4. Cell cycle-dependent expression of mammalian ribonucleotide reductase. Differential regulation of the two subunits.

5. S-Phase-specific expression of mammalian ribonucleotide reductase R1 and R2 subunit mRNAs

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