Loss of Phosphatidylinositol 3-Phosphate Binding by the C-terminal Tiam-1 Pleckstrin Homology Domain Prevents in Vivo Rac1 Activation without Affecting Membrane Targeting-Reference-Cited by-同舟云学术

Loss of Phosphatidylinositol 3-Phosphate Binding by the C-terminal Tiam-1 Pleckstrin Homology Domain Prevents in Vivo Rac1 Activation without Affecting Membrane Targeting

Published:2003-03 Issue:13 Volume:278 Page:11457-11464
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Baumeister Mark A.,Martinu Lenka,Rossman Kent L.,Sondek John,Lemmon Mark A.,Chou Margaret M.

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference56 articles.

1. Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

2. Regulated Membrane Localization of Tiam1, Mediated by the NH2-terminal Pleckstrin Homology Domain, Is Required for Rac-dependent Membrane Ruffling and C-Jun NH2-terminal Kinase Activation

3. Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

4. Mechanism and role of PDZ domains in signaling complex assembly

5. Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

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