Inactivation of the Leishmania tarentolae Pterin Transporter (BT1) and Reductase (PTR1) Genes Leads to Viable Parasites with Changes in Folate Metabolism and Hypersensitivity to the Antifolate Methotrexate
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference45 articles.
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2. Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda
3. Pterin transport and metabolism in Leishmania and related trypanosomatid parasites
4. Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae
5. The Leishmania donovani LD1 locus gene ORFG encodes a biopterin transporter (BT1)
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