Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling
Author:
Funder
National Heart, Lung, and Blood Institute
National Institute of Allergy and Infectious Diseases
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference37 articles.
1. The metabolism of tumors in the body;Warburg;J. Gen. Physiol,1927
2. The emerging hallmarks of cancer metabolism;Pavlova;Cell Metab,2016
3. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate;Ward;Cancer Cell,2010
4. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate;Dang;Nature,2010
5. Hypoxia induces production of l-2-hydroxyglutarate;Intlekofer;Cell Metab,2015
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