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Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State

  • Published:2017-02 Issue:5 Volume:292 Page:1550-1558
  • ISSN:0021-9258
  • Container-title:Journal of Biological Chemistry
  • language:en
  • Short-container-title:Journal of Biological Chemistry

Author:

Fourati Zaineb,Ruza Reinis Reinholds,Laverty Duncan,Drège Emmanuelle,Delarue-Cochin Sandrine,Joseph Delphine,Koehl Patrice,Smart Trevor,Delarue Marc

Funder

Agence Nationale de la Recherche

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference49 articles.

1. The history of barbiturates a century after their clinical introduction;López-Muñoz;Neuropsychiatr. Dis. Treat,2005

2. Pharmacotherapy of tension and anxiety;Lehmann;Curr. Psychiatr. Ther,1972

3. History of the discovery and clinical introduction of chlorpromazine;López-Muñoz;Ann. Clin. Psychiatry,2005

4. Phenobarbital but not diazepam reduces AMPA/kainate receptor mediated currents and exerts opposite actions on initial seizures in the neonatal rat hippocampus;Nardou;Front. Cell. Neurosci,2011

5. Pentobarbital inhibition of human recombinant α1A P/Q-type voltage-gated calcium channels involves slow, open channel block;Schober;Br. J. Pharmacol,2010
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