Crystal structure of the m4-1BB/4-1BBL complex reveals an unusual dimeric ligand that undergoes structural changes upon 4-1BB receptor binding

Author:

Bitra ArunaORCID,Doukov TzankoORCID,Destito Giuseppe,Croft Michael,Zajonc Dirk M.ORCID

Funder

HHS NIH National Institute of Allergy and Infectious Diseases

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference44 articles.

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3. 4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-μ-primed splenic B cells;Pollok;Eur. J. Immunol,1994

4. Role of 4-1BB in immune responses;Vinay;Semin. Immunol,1998

5. T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy;Snell;Immunol. Rev,2011

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