A single mutation increases heavy-chain heterodimer assembly of bispecific antibodies by inducing structural disorder in one homodimer species
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference33 articles.
1. The making of bispecific antibodies;Brinkmann;mAbs,2017
2. Current progress in innovative engineered antibodies;Strohl;Protein Cell,2018
3. Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library;Atwell;J. Mol. Biol,1997
4. Knobs-into-holes’ engineering of antibody CH3 domains for heavy chain heterodimerization;Ridgway;Protein Eng,1996
5. Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG;Gunasekaran;J. Biol. Chem,2010
Cited by 18 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. ISB 2001 trispecific T cell engager shows strong tumor cytotoxicity and overcomes immune escape mechanisms of multiple myeloma cells;Nature Cancer;2024-09-11
2. Micro-second time-resolved X-ray single-molecule internal motions of SARS-CoV-2 spike variants;Biochemistry and Biophysics Reports;2024-07
3. Chemical Production of Cytotoxic Bispecific Antibodies Using the Ugi Multicomponent Reaction;ChemBioChem;2024-06-26
4. Development of a 10 g/L process for a difficult-to-express multispecific antibody format using a holistic process development approach;Journal of Biotechnology;2024-06
5. Mutational biases favor complexity increases in protein interaction networks after gene duplication;Molecular Systems Biology;2024-03-18
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3