Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates

Author:

Stopschinski Barbara E.ORCID,Holmes Brandon B.,Miller Gregory M.,Manon Victor A.,Vaquer-Alicea Jaime,Prueitt William L.,Hsieh-Wilson Linda C.,Diamond Marc I.

Funder

RWTH University Aachen, Faculty of Medicine

Rainwater Charitable Foundation (Tau Consortium)

HHS | National Institutes of Health (NIH)

Medical Scientist Training Program, Washington University St. Louis

Cure Alzheimer's Fund (CAF)

Carl B. and Florence E. King Foundation

University of Texas Southwestern Medical Center

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference35 articles.

1. Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds;Holmes;Proc. Natl. Acad. Sci. U.S.A,2013

2. Demystifying heparan sulfate-protein interactions;Xu;Annu. Rev. Biochem,2014

3. Pathophysiology of heparan sulphate: many diseases, few drugs;Lindahl;J. Intern. Med,2013

4. Heparan sulphate proteoglycans fine-tune mammalian physiology;Bishop;Nature,2007

5. Synthesis of 3-O-sulfated oligosaccharides to understand the relationship between structures and functions of heparan sulfate;Wang;J. Am. Chem. Soc,2017

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