Evolution of New Delhi metallo-β-lactamase (NDM) in the clinic: Effects of NDM mutations on stability, zinc affinity, and mono-zinc activity

Author:

Cheng Zishuo,Thomas Pei W.,Ju Lincheng,Bergstrom Alexander,Mason Kelly,Clayton Delaney,Miller Callie,Bethel Christopher R.,VanPelt Jamie,Tierney David L.,Page Richard C.ORCID,Bonomo Robert A.,Fast Walter,Crowder Michael W.

Funder

HHS | National Institutes of Health (NIH)

National Science Foundation (NSF)

U.S. Department of Veterans Affairs (VA)

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference28 articles.

1. Antibiotic resistance threats in the United States: stepping back from the brink;Solomon;Am. Fam. Physician,2014

2. Vital signs: containment of novel multidrug-resistant organisms and resistance mechanisms–United States, 2006–2017;Woodworth;MMWR Morb. Mortal. Wkly Rep,2018

3. Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability;Makena;J. Antimicrob. Chemother,2015

4. Clinical variants of New Delhi metallo-β-lactamase are evolving to overcome zinc scarcity;Stewart;ACS Infect. Dis,2017

5. Clinical evolution of New Delhi metallo-β-lactamase (NDM) optimizes resistance under Zn(II) deprivation;Bahr;Antimicrob. Agents Chemother,2018

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