A mutant of the Buthus martensii Karsch antitumor-analgesic peptide exhibits reduced inhibition to hNav1.4 and hNav1.5 channels while retaining analgesic activity

Author:

Xu Yijia,Meng Xiangxue,Hou Xue,Sun Jianfang,Kong Xiaohua,Sun Yuqi,Liu Zeyu,Ma Yuanyuan,Niu Ye,Song Yongbo,Cui Yong,Zhao Mingyi,Zhang Jinghai

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference47 articles.

1. Venoms of Buthinae: chemistry and pharmacology of Buthinae scorpion venoms;Zlotkin,1978

2. Structure of scorpion toxins;Possani,1984

3. The biochemical research on scorpion venoms and their application in therapy;Zhou;Progr. Biochem. Biophys,1984

4. Inhibitory effects of recombinant neurotoxin BmK IM on seizures induced by pentylenetetrazol in rats;He;Chin. Med. J,2003

5. Expression of an antitumor-analgesic peptide from the venom of Chinese scorpion Buthus martensii karsch in Escherichia coli;Liu;Protein Expr. Purif,2003

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