AF12198, a Novel Low Molecular Weight Antagonist, Selectively Binds the Human Type I Interleukin (IL)-1 Receptor and Blocks in Vivo Responses to IL-1-Reference-Cited by-同舟云学术

AF12198, a Novel Low Molecular Weight Antagonist, Selectively Binds the Human Type I Interleukin (IL)-1 Receptor and Blocks in Vivo Responses to IL-1

Published:1996-11 Issue:48 Volume:271 Page:30517-30523
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Akeson Ann L.,Woods Connie W.,Hsieh Lily C.,Bohnke Rick A.,Ackermann Bradley L.,Chan Kenneth Y.,Robinson James L.,Yanofsky Stephen D.,Jacobs Jeffrey W.,Barrett Ronald W.,Bowlin Terry L.

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference22 articles.

1. FASEB J.;Dinarello,1994

2. Inhibition of the production and effects of interleukins-1 and tumor necrosis factor α in rheumatoid arthritis

3. Interleukin 1 signaling occurs exclusively via the type I receptor.

4. Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist.

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