Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling-Reference-Cited by-同舟云学术

Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling

Published:2021-01 Issue: Volume:296 Page:100163
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Ceraudo Emilie^ORCID,Horioka Mizuho^ORCID,Mattheisen Jordan M.^ORCID,Hitchman Tyler D.^ORCID,Moore Amanda R.^ORCID,Kazmi Manija A.^ORCID,Chi Ping^ORCID,Chen Yu^ORCID,Sakmar Thomas P.^ORCID,Huber Thomas^ORCID

Funder

National Institutes of Health

U.S. Department of Defense

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference25 articles.

1. Pharmacogenomics of GPCR drug targets;Hauser;Cell,2018

2. Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma;Moore;Nat. Genet.,2016

3. GPCRdb in 2018: adding GPCR structure models and ligands;Pandy-Szekeres;Nucleic Acids Res.,2018

4. The Latest on Uveal Melanoma Research and Clinical Trials: Updates from the Cure Ocular Melanoma (CURE OM) Science Meeting (2019);Chua;Clin. Cancer Res.,2020

5. GNA11 Q209L Mouse model reveals RasGRP3 as an essential signaling Node in uveal melanoma;Moore;Cell Rep.,2018

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