Filipin Prevents Pathological Prion Protein Accumulation by Reducing Endocytosis and Inducing Cellular PrP Release
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference50 articles.
1. The major polypeptide of scrapie-associated fibrils (SAF) has the same size, charge distribution and N-terminal protein sequence as predicted for the normal brain protein (PrP).
2. Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins
3. A cellular gene encodes scrapie PrP 27-30 protein
4. The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.
5. Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing
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