The hsp90-binding Antibiotic Geldanamycin Decreases Raf Levels and Epidermal Growth Factor Signaling without Disrupting Formation of Signaling Complexes or Reducing the Specific Enzymatic Activity of Raf Kinase-Reference-Cited by-同舟云学术

The hsp90-binding Antibiotic Geldanamycin Decreases Raf Levels and Epidermal Growth Factor Signaling without Disrupting Formation of Signaling Complexes or Reducing the Specific Enzymatic Activity of Raf Kinase

Published:1997-02 Issue:7 Volume:272 Page:4013-4020
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Stancato Louis F.,Silverstein Adam M.,Owens-Grillo Janet K.,Chow Yu-Hua,Jove Richard,Pratt William B.

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference44 articles.

1. The pathway to signal achievement

2. Extracellular signals and reversible protein phosphorylation: What to Mek of it all

3. Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase.

4. A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function.

5. Raf-1 N-terminal sequences necessary for Ras-Raf interaction and signal transduction

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