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Tight Control of Hypoxia-inducible Factor-α Transient Dynamics Is Essential for Cell Survival in Hypoxia

  • Published:2014-02 Issue:9 Volume:289 Page:5549-5564
  • ISSN:0021-9258
  • Container-title:Journal of Biological Chemistry
  • language:en
  • Short-container-title:Journal of Biological Chemistry

Author:

Bagnall James,Leedale Joseph,Taylor Sarah E.,Spiller David G.,White Michael R.H.,Sharkey Kieran J.,Bearon Rachel N.,Sée Violaine

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference39 articles.

1. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis;Maxwell;Nature,1999

2. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors;Sowter;Cancer Res,2001

3. Is HIF-1α a pro- or an anti-apoptotic protein?;Piret;Biochem. Pharmacol,2002

4. Do VHL and HIF-1 mirror p53 and Mdm-2? Degradation-transactivation loops of oncoproteins and tumor suppressors;Blagosklonny;Oncogene,2001

5. Dynamics of the p53-Mdm2 feedback loop in individual cells;Lahav;Nat. Genet,2004
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