Generation of Aβ38 and Aβ42 Is Independently and Differentially Affected by Familial Alzheimer Disease-associated Presenilin Mutations and γ-Secretase Modulation-Reference-Cited by-同舟云学术

Generation of Aβ38 and Aβ42 Is Independently and Differentially Affected by Familial Alzheimer Disease-associated Presenilin Mutations and γ-Secretase Modulation

Published:2008-01 Issue:2 Volume:283 Page:677-683
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Page Richard M.,Baumann Karlheinz,Tomioka Masanori,Pérez-Revuelta Blanca I.,Fukumori Akio,Jacobsen Helmut,Flohr Alexander,Luebbers Thomas,Ozmen Laurence,Steiner Harald,Haass Christian

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference34 articles.

1. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

2. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

3. Take five—BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation

4. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

5. Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

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