The 1.6-Å Crystal Structure of the Copper(II)-bound Bleomycin Complexed with the Bleomycin-binding Protein from Bleomycin-producing Streptomyces verticillus-Reference-Cited by-同舟云学术

The 1.6-Å Crystal Structure of the Copper(II)-bound Bleomycin Complexed with the Bleomycin-binding Protein from Bleomycin-producing Streptomyces verticillus

Published:2002-01 Issue:3 Volume:277 Page:2311-2320
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Sugiyama Masanori,Kumagai Takanori,Hayashida Minoru,Maruyama Masafumi,Matoba Yasuyuki

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference46 articles.

1. Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA.

2. Mechanisms of bleomycin-induced DNA degradation

3. A role for the metal binding domain in determining the DNA sequence selectivity of Fe-bleomycin.

4. On the role of the bithiazole moiety in sequence-selective DNA cleavage by Fe.bleomycin.

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