Secondary Substrate-binding Exosite in the Serine Protease Domain of Activated Protein C Important for Cleavage at Arg-506 but Not at Arg-306 in Factor Va
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference24 articles.
1. The coagulation cascade: initiation, maintenance, and regulation
2. The Protein C Pathway: New Insights
3. Blood coagulation
4. The molecular basis of blood coagulation
5. The mechanism of inactivation of human factor V and human factor Va by activated protein C.
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1. Design and characterization of novel activated protein C variants for the proteolysis of cytotoxic extracellular histone H3;Journal of Thrombosis and Haemostasis;2023-12
2. Ser252Asn Mutation Introduces a New N-Linked Glycosylation Site and Causes Type IIb Protein C Deficiency;Thrombosis and Haemostasis;2023-11-27
3. Thrombosis and Inflammation—A Dynamic Interplay and the Role of Glycosaminoglycans and Activated Protein C;Frontiers in Cardiovascular Medicine;2022-03-31
4. Selective Modulation of the Protease Activated Protein C Using Exosite Inhibiting Aptamers;Nucleic Acid Therapeutics;2020-10-01
5. Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia;Nature Communications;2020-06-12
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