Combined Rational Design and a High Throughput Screening Platform for Identifying Chemical Inhibitors of a Ras-activating Enzyme-Reference-Cited by-同舟云学术

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Combined Rational Design and a High Throughput Screening Platform for Identifying Chemical Inhibitors of a Ras-activating Enzyme

Published:2015-05 Issue:20 Volume:290 Page:12879-12898
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Evelyn Chris R.,Biesiada Jacek,Duan Xin,Tang Hong,Shang Xun,Papoian Ruben,Seibel William L.,Nelson Sandra,Meller Jaroslaw,Zheng Yi

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference52 articles.

1. Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?;Vigil;Nat. Rev. Cancer,2010

2. Dbl family guanine nucleotide exchange factors;Zheng;Trends Biochem. Sci,2001

3. RAS oncogenes: weaving a tumorigenic web;Pylayeva-Gupta;Nat. Rev. Cancer,2011

4. Ras history: The saga continues;Cox;Small GTPases,2010

5. Germline gain-of-function mutations in SOS1 cause Noonan syndrome;Roberts;Nat. Genet,2007

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