Increased Hydrophobicity at the N Terminus/Membrane Interface Impairs Gating of the Severe Combined Immunodeficiency-related ORAI1 Mutant-Reference-Cited by-同舟云学术

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Increased Hydrophobicity at the N Terminus/Membrane Interface Impairs Gating of the Severe Combined Immunodeficiency-related ORAI1 Mutant

Published:2009-06 Issue:23 Volume:284 Page:15903-15915
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Derler Isabella,Fahrner Marc,Carugo Oliviero,Muik Martin,Bergsmann Judith,Schindl Rainer,Frischauf Irene,Eshaghi Said,Romanin Christoph

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference64 articles.

1. The multiple causes of human SCID

2. Current topic: Severe combined immunodeficiency---molecular pathogenesis and diagnosis

3. Immunodeficiency Is A Tough Nut to CRAC: The Importance of Calcium Flux in T Cell Activation

4. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

5. A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients

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2. Side-by-side comparison of published small molecule inhibitors against thapsigargin-induced store-operated Ca2+ entry in HEK293 cells;PLOS ONE;2024-01-23

3. The role of ion channels in immune-related diseases;Progress in Biophysics and Molecular Biology;2023-01

4. The Role of Lipids in CRAC Channel Function;Biomolecules;2022-02-23

5. Highlighting the Multifaceted Role of Orai1 N-Terminal- and Loop Regions for Proper CRAC Channel Functions;Cells;2022-01-22

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