The Glycine-Alanine Dipeptide Repeat from C9orf72 Hexanucleotide Expansions Forms Toxic Amyloids Possessing Cell-to-Cell Transmission Properties
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference31 articles.
1. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS;DeJesus-Hernandez;Neuron,2011
2. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD;Renton;Neuron,2011
3. p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS;Al-Sarraj;Acta Neuropathol,2011
4. C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis;Rohrer;Lancet Neurol,2015
5. Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood;Belzil;Acta Neuropathol,2013
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1. C9orf72-associated dipeptide protein repeats form A11-positive oligomers in amyotrophic lateral sclerosis and frontotemporal dementia;Journal of Biological Chemistry;2024-02
2. ALS’ Perfect Storm: C9orf72-Associated Toxic Dipeptide Repeats as Potential Multipotent Disruptors of Protein Homeostasis;Cells;2024-01-17
3. CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology;Science Advances;2023-11-10
4. Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity;Acta Neuropathologica Communications;2023-08-29
5. Intercellular transmission of pathogenic proteins in ALS: Exploring the pathogenic wave;Neurobiology of Disease;2023-08
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