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Thiopurine Prodrugs Mediate Immunosuppressive Effects by Interfering with Rac1 Protein Function

  • Published:2016-06 Issue:26 Volume:291 Page:13699-13714
  • ISSN:0021-9258
  • Container-title:Journal of Biological Chemistry
  • language:en
  • Short-container-title:Journal of Biological Chemistry

Author:

Shin Jin-Young,Wey Michael,Umutesi Hope G.,Sun Xiangle,Simecka Jerry,Heo Jongyun

Funder

National Institutes of Health

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference54 articles.

1. Acute myeloid leukaemia in children;Langmuir;Best Pract. Res. Clin. Haematol,2001

2. The purine path to chemotherapy;Elion;Science,1989

3. Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease;Gearry;J. Gastroenterol. Hepatol,2005

4. Repair defect in p21 WAF1/CIP1−/− human cancer cells;McDonald;Cancer Res,1996

5. CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes;Tiede;J. Clin. Invest,2003

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