Hydroxyproline-induced Helical Disruption in Conantokin Rl-B Affects Subunit-selective Antagonistic Activities toward Ion Channels of N-Methyl-d-aspartate Receptors

Author:

Kunda Shailaja,Yuan Yue,Balsara Rashna D.,Zajicek Jaroslav,Castellino Francis J.

Funder

National Institutes of Health

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference82 articles.

1. Conantokin-T. A γ-carboxyglutamate containing peptide with N-methyl-d-aspartate antagonist activity;Haack;J. Biol. Chem,1990

2. In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus;White;J. Pharmacol. Exp. Ther,2000

3. Crystal structure of a heterotetrameric NMDA receptor ion channel;Karakas;Science,2014

4. Zinc potentiates agonist-induced currents at certain splice variants of the NMDA receptor;Hollmann;Neuron,1993

5. The three-dimensional structure of an ionotropic glutamate receptor reveals a dimer-of-dimers assembly;Tichelaar;J. Mol. Biol,2004

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