Reactive Metabolite-induced Protein Glutathionylation: A Potentially Novel Mechanism Underlying Acetaminophen Hepatotoxicity

Author:

Chan James Chun YipORCID,Soh Alex Cheow Khoon,Kioh Dorinda Yan Qin,Li Jianguo,Verma Chandra,Koh Siew Kwan,Beuerman Roger Wilmer,Zhou Lei,Chan Eric Chun YongORCID

Funder

Ministry of Education - Singapore

Singapore National Medical Research Council

Publisher

Elsevier BV

Subject

Molecular Biology,Biochemistry,Analytical Chemistry

Reference74 articles.

1. Molecular mechanisms and clinical implications of reversible protein S-glutathionylation;Mieyal;Antioxidants Redox Signaling,2008

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3. Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo;Jollow;The Journal Of Pharmacology And Experimental Therapeutics,1973

4. Mechanisms of acetaminophen-induced liver necrosis;Hinson;Handbook Exp. Pharmacol,2010

5. Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione;Knight;J. Pharmacol. Exp. Therapeutics,2002

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