Enhanced Killing of Cancer Cells by Poly(ADP-ribose) Polymerase Inhibitors and Topoisomerase I Inhibitors Reflects Poisoning of Both Enzymes

Author:

Patel Anand G.,Flatten Karen S.,Schneider Paula A.,Dai Nga T.,McDonald Jennifer S.,Poirier Guy G.,Kaufmann Scott H.

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference99 articles.

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2. Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II;Potmesil;Cancer Res.,1988

3. DNA topoisomerases. Structure, function, and mechanism;Champoux;Annu. Rev. Biochem.,2001

4. DNA topoisomerases and their poisoning by anticancer and antibacterial drugs;Pommier;Chem. Biol.,2010

5. Quantitation of eukaryotic topoisomerase I reactivity with DNA. Preferential cleavage of supercoiled DNA;Muller;Biochim. Biophys. Acta,1985

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