A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis

Author:

Ito Shinya,Ogawa Koji,Takeuchi Koh,Takagi Motoki,Yoshida Masahito,Hirokawa Takatsugu,Hirayama Shoshiro,Shin-ya Kazuo,Shimada Ichio,Doi Takayuki,Goshima Naoki,Natsume Tohru,Nagata Kazuhiro

Funder

Core Research for Evolutional Science and Technology

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference34 articles.

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2. Mechanisms of fibrosis: therapeutic translation for fibrotic disease;Wynn;Nat. Med,2012

3. The prolyl 4-hydroxylase inhibitor HOE 077 prevents activation of Ito cells, reducing procollagen gene expression in rat liver fibrosis induced by choline-deficient l-amino acid-defined diet;Sakaida;Hepatology,1996

4. Selective inhibition of hepatic collagen accumulation in experimental liver fibrosis in rats by a new prolyl 4-hydroxylase inhibitor;Bickel;Hepatology,1998

5. A novel small compound that promotes nuclear translocation of YB-1 ameliorates experimental hepatic fibrosis in mice;Higashi;J. Biol. Chem,2011

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