The C-terminal dimerization domain of the respiratory mucin MUC5B functions in mucin stability and intracellular packaging before secretion

Author:

Ridley Caroline,Lockhart-Cairns Michael P.,Collins Richard F.,Jowitt Thomas A.,Subramani Durai B.,Kesimer Mehmet,Baldock Clair,Thornton David J.

Funder

UK Research and Innovation | Medical Research Council

Cystic Fibrosis Foundation Therapeutics

Cystic Fibrosis Foundation

Wellcome Trust

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference66 articles.

1. Mucins: the frontline defence of the lung;Ridley;Biochem. Soc. Trans,2018

2. Role of mucins in lung homeostasis: regulated expression and biosynthesis in health and disease;Symmes;Biochem. Soc. Trans,2018

3. Airway mucus and asthma: the role of MUC5AC and MUC5B;Bonser;J. Clin. Med,2017

4. Mucus hyperconcentration as a unifying aspect of the chronic bronchitic phenotype;Button;Ann. Am. Thorac Soc,2016

5. Pathological mucus and impaired mucus clearance in cystic fibrosis patients result from increased concentration, not altered pH;Hill;Eur. Respir. J,2018

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