Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region
Author:
Funder
British Heart Foundation (BHF)
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference28 articles.
1. Molecular and functional properties of P2X receptors-recent progress and persisting challenges;Kaczmarek-Háajek;Purinergic Signal,2012
2. Signaling at purinergic P2X receptors;Surprenant;Annu. Rev. Physiol,2009
3. Pathophysiology and therapeutic potential of purinergic signaling;Burnstock;Pharmacol. Rev,2006
4. Receptors for purines and pyrimidines;Ralevic;Pharmacol. Rev,1998
5. PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses;Lambrecht;Eur. J. Pharmacol,1992
Cited by 19 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Deficiency of purinergic P2X4 receptor alleviates experimental autoimmune hepatitis in mice;Biochemical Pharmacology;2024-03
2. P2X7 receptor activation leads to NLRP3-independent IL-1β release by human macrophages;Cell Communication and Signaling;2023-11-23
3. Epithelial wound healing in Clytia hemisphaerica provides insights into extracellular ATP signaling mechanisms and P2XR evolution;Scientific Reports;2023-11-01
4. Sympathetic Nervous System Co-Transmitters ATP and Norepinephrine Oppositely Modulate Antibody Production in the Rat Spleen under Deep Cooling;Journal of Evolutionary Biochemistry and Physiology;2023-11
5. Structural insights into the orthosteric inhibition of P2X receptors by non-ATP-analog antagonists;2023-09-17
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3