DLC1 SAM domain-binding peptides inhibit cancer cell growth and migration by inactivating RhoA

Author:

Joshi RakeshORCID,Qin Lyugao,Cao Xuan,Zhong Shanshan,Voss Courtney,Min Weiping,Li Shawn S.C.

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference56 articles.

1. Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells;Zhou;Oncogene,2004

2. Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma;Wong;PLoS ONE,2008

3. DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma;Xue;Genes Dev,2008

4. DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis;Zhou;Int. J. Oncol,2008

5. DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development;Durkin;FEBS Lett,2005

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