A Composite Renal Tumor: Metanephric Adenofibroma, Wilms Tumor, and Renal Cell Carcinoma: A Missing Link?

Author:

Galluzzo Maria Laura1,de Davila Maria T. Garcia1,Vujanić Gordan M.2

Affiliation:

1. Department of Pathology, Hospital Nacional de Pediatría JP Garrahan, Buenos Aires, Argentina

2. Department of Histopathology, Cardiff University School of Medicine, Cardiff, Wales, United Kingdom

Abstract

A coexistence of different renal tumors has rarely been reported. The most commonly described association is of Wilms tumor and renal cell carcinoma. Metanephric adenofibroma has also been associated with Wilms tumor or papillary renal cell carcinoma. Another reported association is metanephric adenoma and papillary renal cell carcinoma with sarcomatoid dedifferentiation. Herein we describe a complex renal tumor containing areas of metanephric adenofibroma, Wilms tumor, and undifferentiated renal cell carcinoma in a previously healthy 18-year-old boy. The tumor showed histologic and immunohistochemical features of these 3 different tumors, offering additional support to the view that these 3 tumors are related.

Publisher

SAGE Publications

Subject

General Medicine,Pathology and Forensic Medicine,Pediatrics, Perinatology and Child Health

Cited by 11 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Renal Tumors of Adults;Tumors of the Kidney, Bladder, and Related Urinary Structures;2021-11

2. Paediatric metanephric tumours: a clinicopathological and molecular characterisation;Critical Reviews in Oncology/Hematology;2020-06

3. Neoplasms of the Kidney;Urologic Surgical Pathology;2020

4. Benign Renal Epithelial / Epithelial and Stromal Tumors;Kidney Cancer;2019-11-28

5. Metanephric Adenofibroma in a young adult;International braz j urol;2017-06

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