Placental Mesenchymal Dysplasia without Fetal Development in a Twin Gestation: A Case Report and Review of the Spectrum of Androgenetic Biparental Mosaicism-Reference-Cited by-同舟云学术

Placental Mesenchymal Dysplasia without Fetal Development in a Twin Gestation: A Case Report and Review of the Spectrum of Androgenetic Biparental Mosaicism

Published:2015-03 Issue:2 Volume:18 Page:146-154
ISSN:1093-5266
Container-title:Pediatric and Developmental Pathology
language:en
Short-container-title:Pediatr Dev Pathol

Author:

Linn Rebecca L.¹,Minturn Lucy¹,Yee Lynn M.²,Maniar Kruti¹,Zhang Yanming¹,Fritsch Michael K.¹,Kashireddy Papreddy¹,Kapur Raj³,Ernst Linda M.¹

Affiliation:

1. Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

2. Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

3. Department of Pathology, Seattle Children's Hospital, Seattle, WA, USA

Abstract

We report a dichorionic twin gestation with diffuse placental mesenchymal dysplasia (PMD) and androgenetic biparental mosaicism (ABM) involving one twin's placenta with complete absence of fetal development for that twin. To our knowledge, this is the 1st reported case of PMD without fetal development. We discuss the gross, histologic, and genetic hallmarks of PMD and the spectrum of variability depending on degree and distribution of ABM.

Publisher

SAGE Publications

Subject

General Medicine,Pathology and Forensic Medicine,Pediatrics, Perinatology, and Child Health

Link

http://journals.sagepub.com/doi/pdf/10.2350/14-12-1583-CR.1

Reference36 articles.

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4. Placental Mesenchymal Dysplasia Is Associated With High Rates of Intrauterine Growth Restriction and Fetal Demise

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