Myelodysplastic Syndrome with Pulmonary Tumor Thrombotic Microangiopathy in an 11-Year-Old Male Patient

Author:

Perrino Carmen M.1,Dehner Louis P.1,Hartman Mary E.2,Agarwal Ashima1

Affiliation:

1. Department of Pathology and Immunology, Washington University, Campus Box 8118, 660 South Euclid Ave., St. Louis, MO 63110, USA

2. Department of Pediatrics, Washington University, Campus Box 8116, 660 S. Euclid Ave., St. Louis, MO 63110, USA

Abstract

Myelodysplastic syndrome (MDS) and pulmonary tumor thrombotic microangiopathy (PTTM) are independently rare in the pediatric population. This report describes an 11-year-old male patient who initially presented with respiratory distress and cardiovascular collapse. A large left main pulmonary artery embolus and multiple, smaller pulmonary thromboemboli were widely dispersed throughout both lungs. Despite aggressive supportive care, he died within seven hours of admission. A complete postmortem examination was performed, leading to the diagnoses of primary MDS and microthrombi in the lungs, including the characteristic fibroproliferative lesions seen in PTTM. Individually, both conditions are extremely uncommon, and therefore the coincidence of these 2 conditions in a child is singularly unique.

Publisher

SAGE Publications

Subject

General Medicine,Pathology and Forensic Medicine,Pediatrics, Perinatology, and Child Health

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Pulmonary tumor thrombotic microangiopathy: a systematic review;Pulmonary Circulation;2019-04

2. Microangiopathie thrombotique tumorale pulmonaire;Revue des Maladies Respiratoires;2017-12

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