Acephaly: Further Evidence for Disruption but Not for Amniotic Bands

Author:

Mazzitelli Nancy1,Vauthay Liliana2,Oliveri Jaen34,Maccarone Belen3,Rittler Monica3

Affiliation:

1. Pathology Unit, Department of Diagnostics, Hospital Materno Infantil Ramón Sardá, University of Buenos Aires, Argentina

2. Department of Cell Biology, Histology, Embryology and Genetics, School of Medicine, University of Buenos Aires, Argentina

3. Medical Genetics Section, Department of Neonatology, Hospital Materno Infantil Ramón Sardá, University of Buenos Aires, Argentina

4. National Centre of Medical Genetics, Buenos Aires, Argentina

Abstract

Complete absence of the fetal head in singleton pregnancies is a very rare defect; to our knowledge there are only 7 reported cases. Decapitation by amniotic bands has been considered as the most probable cause. However, in none of the described cases except one were amniotic bands, constriction rings, or other related findings observed, raising the possibility that mechanisms other than amputation by amniotic bands are involved. We present a further case of acephaly and discuss the role of amniotic bands and alternative mechanisms of decapitation and a possible sequence of events leading to acephaly.

Publisher

SAGE Publications

Subject

General Medicine,Pathology and Forensic Medicine,Pediatrics, Perinatology and Child Health

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