CD5-Positive B-Cell Acute Lymphoblastic Leukemia-Reference-Cited by-同舟云学术

CD5-Positive B-Cell Acute Lymphoblastic Leukemia

Published:2007-01 Issue:1 Volume:10 Page:41-45
ISSN:1093-5266
Container-title:Pediatric and Developmental Pathology
language:en
Short-container-title:Pediatr Dev Pathol

Author:

Peterson Michael R.¹,Noskoviak Kyle J.¹,Newbury Robert²

Affiliation:

1. Department of Pathology, University of California, San Diego, CA 92093, USA

2. Department of Pathology, Children's Hospital and Health Center of San Diego, San Diego, CA 92123, USA

Abstract

CD5-positive B-cell acute lymphoblastic leukemia (ALL) is an exceedingly rare entity, with only a single case report in the literature. We report 2 additional cases of CD5-positive B-cell ALL in a 16-year-old male and a 15-year-old female. The 1st case was initially misdiagnosed as Ewing sarcoma due to a lack of CD45 expression and weak expression of CD99. Cytogenetic analysis of the 2nd case revealed trisomy 22, the 1st time this finding has been reported in ALL. Both patients had poor outcomes, as did the patient in the previously published case report. We conclude that CD5-positive B-cell ALL is a rare, aggressive malignancy with a poor prognosis that presents in adolescence. Pathologists and clinicians should be aware of this entity to avoid confusion with other small blue-cell tumors.

Publisher

SAGE Publications

Subject

General Medicine,Pathology and Forensic Medicine,Pediatrics, Perinatology and Child Health

Link

http://journals.sagepub.com/doi/pdf/10.2350/06-03-0057.1

Reference8 articles.

1. The CD5 B Cell

2. CD19/CD5 acute lymphoblastic leukemia

3. Acute lymphoblastic leukemia with the phenotype of a putative B-cell/T-cell bipotential precursor

4. Classification of acute leukemias

5. Lack of CD45 antigen on blast cells in childhood acute lymphoblastic leukemia is associated with chromosomal hyperdiploidy and other favorable prognostic features [see comments]

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