Is CRX Protein a Useful Marker in Differential Diagnosis of Tumors of the Pineal Region?-Reference-Cited by-同舟云学术

Is CRX Protein a Useful Marker in Differential Diagnosis of Tumors of the Pineal Region?

Published:2014-03 Issue:2 Volume:17 Page:85-88
ISSN:1093-5266
Container-title:Pediatric and Developmental Pathology
language:en
Short-container-title:Pediatr Dev Pathol

Author:

Manila Antonelli¹,Mariangela Novello²,Libero Lauriola²,Francesca Gianno¹,Romana Buttarelli Francesca³,Felice Giangaspero¹⁴

Affiliation:

1. Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University Viale Regina Elena 324, 00161 Rome, Italy

2. Department of Pathology, Policlinico Gemelli Largo Agostino Gemelli 8, 00168 Rome, Italy

3. Department of Neurology and Psychiatry, Sapienza University Viale dell'Università, 30, 00161 Rome, Italy

4. IRCCS Neuromed, Via Artinese 18, 86077 Pozzilli, Italy

Abstract

The cone-rod homeobox (CRX) is a gene that belongs to the member of the orthodenticle homeobox (Otx) family, with important function in development and differentiation of retinal and pineal cells. Moreover, CRX appears to be specifically expressed in pineal tumors and retinoblastomas. We performed an immunohistochemical study on 91 pediatric and adult central nervous system tumors, plus 2 normal brain samples. Our results demonstrated that CRX is expressed not only in pineal parenchymal tumors and retinoblastoma, but also in a some medulloblastomas and supratentorial primitive neuroectodermal tumors. None of the glial tumors screened were positive for CRX. In conclusion, CRX could be useful in surgical neuropathology for the differential diagnosis of pineal region tumors, in particular to discriminate pineal tumors from glial tumors.

Publisher

SAGE Publications

Subject

General Medicine,Pathology and Forensic Medicine,Pediatrics, Perinatology and Child Health

Link

http://journals.sagepub.com/doi/pdf/10.2350/13-06-1346-OA.1

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