Impact of intravenous rt-PA and additional antithrombotic agents within 24 hours on atherothrombotic large vessel occlusion requiring emergency neuroendovascular revascularization

Author:

Miyazaki Takeshi1,Himeno Takahiro2,Miyazaki Yuko1,Kori Ryusuke1,Inoue Tomoyuki2,Sato Kota2,Sato Tatsuya2,Fukushima Tomoko3,Ota Shinzo1

Affiliation:

1. Department of Neurosurgery, Brain Attack Center Ota Memorial Hospital

2. Department of Neurology, Brain Attack Center Ota Memorial Hospital

3. Fukuyama Cerebrovascular and Medical Laboratory, Brain Attack Center Ota Memorial Hospital

Publisher

Japan Stroke Society

Subject

General Medicine

Reference14 articles.

1. 1) Yang P, Zhang Y, Zhang L, et al.: Endovascular thrombectomy with or without intravenous alteplase in acute stroke. N Engl J Med 382: 1981–1993, 2020

2. 2) Zi W, Qiu Z, Li F, et al.: Effect of endovascular treatment alone vs intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke: The DEVT randomized clinical trial. JAMA 325: 234–243, 2021

3. 3) Suzuki K, Matsumaru Y, Takeuchi M, et al.: Effect of mechanical thrombectomy without vs with intravenous thrombolysis on functional outcome among patients with acute ischemic stroke: The SKIP randomized clinical trial. JAMA 325: 244–253, 2021

4. 4) LeCouffe NE, Kappelhof M, Treurniet KM, et al.: A randomized trial of intravenous alteplase before endovascular treatment for stroke. N Engl J Med 385: 1833–1844, 2021

5. 5) Mitchell PJ, Yan B, Churilov L, et al.: Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial. Lancet 400: 116–125, 2022

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