Optical coherence elastography to evaluate depth-resolved elasticity of tissue

Abstract

Skin-elasticity measurements can assist in the clinical diagnosis of skin diseases, which has important clinical significance. Accurately determining the depth-resolved elasticity of superficial biological tissue is an important research direction. This paper presents an optical coherence elastography technique that combines surface acoustic waves and shear waves to obtain the elasticity of multilayer tissue. First, the phase velocity of the high-frequency surface acoustic wave is calculated at the surface of the sample to obtain the Young's modulus of the top layer. Then, the shear wave velocities in the other layers are calculated to obtain their respective Young's moduli. In the bilayer phantom experiment, the maximum error in the elastic estimation of each layer was 2.2%. The results show that the proposed method can accurately evaluate the depth-resolved elasticity of layered tissue-mimicking phantoms, which can potentially expand the clinical applications of elastic wave elastography.