Affiliation:
1. Univ. Lille
2. Lightcore Technologies
3. Aix Marseille Univ.
Abstract
We demonstrate a 2 mm diameter highly multimodal nonlinear micro-endoscope allowing label-free imaging of biological tissues. The endoscope performs multiphoton fluorescence (3-photon, 2-photon), harmonic generation (second-SHG and third-THG) and coherent anti-Stokes Raman scattering (CARS) imaging over a field of view of 200 µm. The micro-endoscope is based on a double-clad antiresonant hollow core fiber featuring a high transmission window (850 nm to 1800 nm) that is functionalized with a short piece of graded-index (GRIN) fiber. When combined with a GRIN micro-objective, the micro-endoscope achieves a 1.1 µm point spread function (PSF). We demonstrate 3-photon, 2-photon, THG, SHG, and CARS high resolution images of unlabelled biological tissues.
Funder
Institut National de la Santé et de la Recherche Médicale
Aix-Marseille Université
Région Hauts-de-France
Ministère de l'Education Nationale, de l'Enseignement Supérieur et de la Recherche
National Institutes of Health
Agence Nationale de la Recherche
Subject
Atomic and Molecular Physics, and Optics
Cited by
7 articles.
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