Polarization microwave-induced thermoacoustic imaging for quantitative characterization of deep biological tissue microstructures

Author:

Li Yujing1,Zhang Shanxiang1,Wu Linghua1,Cheng Zhongwen1,Zhang Zhenhui1,Wang Haohao1,Zhao Shuxiang1,Ren Mingyang1,Yang Sihua1ORCID,Xing Da1,Qin Huan1

Affiliation:

1. South China Normal University

Abstract

Polarization optical imaging can be used to characterize anisotropy in biological tissue microstructures and has been demonstrated to be a powerful tool for clinical diagnosis. However, the approach is limited by an inability to image targets deeper than 1    mm due to strong optical scattering in biological tissues. As such, we propose a novel polarization microwave-induced thermoacoustic imaging (P-MTAI) technique to noninvasively detect variations in deep tissue by exploiting the thermoacoustic signals induced by four pulsed microwaves of varying polarization orientations. The proposed P-MTAI method overcomes the penetration limits of conventional polarization optical imaging and provides submillimeter resolution over depths of several centimeters. As part of the paper, the structural characteristics of tissues were quantified using a new parameter, the degree of microwave absorption anisotropy. P-MTAI was also applied to the noninvasive detection of morphological changes in cardiomyocytes as they transitioned from ordered to disordered states, providing a potential indication of myocardial infarction.

Funder

National Natural Science Foundation of China

Science and Technology Planning Project of Guangdong Province

Science and Technology Program of Guangzhou

Publisher

Optica Publishing Group

Subject

Atomic and Molecular Physics, and Optics,Electronic, Optical and Magnetic Materials

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