Terahertz polarization sensing for protein concentration and a crystallization process on a reflective metasurface

Author:

Zhang Tianrui1,Fan Fei1,Cheng Jierong1,Wang Xianghui1,Chang Shengjiang2

Affiliation:

1. Nankai University

2. Tianjin Key Laboratory of Optoelectronic Sensor and Sensing Network Technology

Abstract

Terahertz (THz) waves have attracted much attention in the field of biosensing due to advantages including non-destructiveness, being label-free, and high-sensitivity detection. Here we have experimentally demonstrated a THz polarization sensing method based on reflective metasurface sensors for detecting concentrations of protein solutions and their crystallization process. The protein with varying concentrations has been detected by five different polarization parameters, which show different spectral responses and sensing sensitivities. The sensing accuracy can reach the order of n g / m m 2 . Furthermore, the crystallization process of the protein sample from the dissolved state to the crystalline has been dynamically measured by polarization sensing, of which the highest sensitivity can reach 0.67 °/%. Therefore, this new sensing platform can have broad development prospects in the trace matter detection of the biological sample.

Funder

Natural Science Foundation of Tianjin City

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Optica Publishing Group

Subject

Atomic and Molecular Physics, and Optics,Engineering (miscellaneous),Electrical and Electronic Engineering

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