Affiliation:
1. Faculty of Medicine of Masaryk University and St. Anne’s, University Hospital
Abstract
Pathogenic microbes contribute to several major global diseases that kill millions of people every year. Bloodstream infections caused by these microbes are associated with high morbidity and mortality rates, which are among the most common causes of hospitalizations. The search for the “Holy Grail” in clinical diagnostic microbiology, a reliable, accurate, low cost, real-time, and easy-to-use diagnostic method, is one of the essential issues in clinical practice. These very critical conditions can be met by Raman tweezers in combination with advanced analysis methods. Here, we present a proof-of-concept study based on Raman tweezers combined with spectral mixture analysis that allows for the identification of microbial strains directly from human blood serum without user intervention, thus eliminating the influence of a data analyst.
Funder
Ministerstvo Zdravotnictví Ceské Republiky
Technology Agency of the Czech Republic
Ministerstvo Průmyslu a Obchodu
Akademie Věd České Republiky
Subject
Atomic and Molecular Physics, and Optics,Biotechnology
Cited by
1 articles.
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