Diffuse reflectance spectroscopy sensor to differentiate between glial tumor and healthy brain tissue: a proof-of-concept study

Author:

Skyrman Simon1ORCID,Burström Gustav1ORCID,Lai Marco23,Manni Francesca3ORCID,Hendriks Benno24,Frostell Arvid1,Edström Erik1,Persson Oscar1,Elmi-Terander Adrian15ORCID

Affiliation:

1. Karolinska University Hospital

2. Philips Research

3. Eindhoven University of Technology (TU/e)

4. Delft University of Technology

5. Stockholm Spine Center

Abstract

Glial tumors grow diffusely in the brain. Survival is correlated to the extent of tumor removal, but tumor borders are often invisible. Resection beyond the borders as defined by conventional methods may further improve prognosis. In this proof-of-concept study, we evaluate diffuse reflectance spectroscopy (DRS) for discrimination between glial tumors and normal brain ex vivo. DRS spectra and histology were acquired from 22 tumor samples and nine brain tissue samples retrieved from 30 patients. The content of biological chromophores and scattering features were estimated by fitting a model derived from diffusion theory to the DRS spectra. DRS parameters differed significantly between tumor and normal brain tissue. Classification using random forest yielded a sensitivity and specificity for the detection of low-grade gliomas of 82.0% and 82.7%, respectively, and the area under curve (AUC) was 0.91. Applied in a hand-held probe or biopsy needle, DRS has the potential to provide intra-operative tissue analysis.

Funder

Stockholms Läns Landsting

Publisher

Optica Publishing Group

Subject

Atomic and Molecular Physics, and Optics,Biotechnology

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