Quantitative x-ray fluorescence imaging system for non-destructive 3D tumor histology

Author:

Pu Shaozhou1ORCID,Huang Yunwen1,Zhao Ning1,Liu Hui1,Zuo Yang1,Zheng Cheng1,Zhou Hangcheng1,Zhu Lei1,Yang Yidong1

Affiliation:

1. University of Science and Technology of China

Abstract

An in-house dual-modality x-ray fluorescence tomography (XFT) and x-ray computed tomography (XCT) system was developed to quantify iodine contrast distribution through the whole tumor volume ex vivo. The quantitative XFT was calibrated with water phantoms containing iodine solutions of various concentrations (0.0175–1.4 wt.%). The vasculature distribution was reflected by the iodine perfusion, which was validated with histology. This technique may open a new, to the best of our knowledge, route to the non-destructive three-dimensional-imaging-based histological analysis of tumor samples.

Funder

Fundamental Research Funds for the Central Universities

Anhui Provincial-Level S&T Megaprojects

Publisher

Optica Publishing Group

Subject

Atomic and Molecular Physics, and Optics

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Benchtop cone-beam X-ray fluorescence CT system with high sensitivity and high spatial resolution;2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD);2023-11-04

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