Affiliation:
1. Engineering Research Center of Molecular and Neuro Imaging
2. University of Macau
3. Xidian University
Abstract
Histopathology is the foundation and gold standard for identifying diseases, and precise quantification of histopathological images can provide the pathologist with objective clues to make a more convincing diagnosis. Optical microscopy (OM), an important branch of optical imaging technology that provides high-resolution images of tissue cytology and structural morphology, has been used in the diagnosis of histopathology and evolved into a new disciplinary direction of optical microscopic histopathology (OMH). There are a number of ex-vivo studies providing applicability of different OMH approaches, and a transfer of these techniques toward in vivo diagnosis is currently in progress. Furthermore, combined with advanced artificial intelligence algorithms, OMH allows for improved diagnostic reliability and convenience due to the complementarity of retrieval information. In this review, we cover recent advances in OMH, including the exploration of new techniques in OMH as well as their applications, and look ahead to new challenges in OMH. These typical application examples well demonstrate the application potential and clinical value of OMH techniques in histopathological diagnosis.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
National Ten Thousand Talent Program
Young Talent Support Program of Shaanxi Province University
Key Research and Development Projects of Shaanxi Province
Fundamental Research Funds for the Central Universities
Subject
Atomic and Molecular Physics, and Optics,Biotechnology