Non-invasive chemically selective energy delivery and focusing inside a scattering medium guided by Raman scattering

Abstract

Raman scattering is a chemically selective probing mechanism with diverse applications in industry and clinical settings. Yet, most samples are optically opaque limiting the applicability of Raman probing at depth. Here, we demonstrate chemically selective energy deposition behind a scattering medium by combining prior information on the chemical’s spectrum with the measurement of a spectrally resolved Raman speckle as a feedback mechanism for wavefront shaping. We demonstrate unprecedented sixfold signal enhancement in an epi-geometry, realizing targeted energy deposition and focusing on individual Raman active particles.