Multi-objective optimization of custom compound prism arrays for multiplexed optical imaging

Author:

Price Liam J.1ORCID,Tatz Julia12,Sutin Jason2,Spring Bryan Q.1ORCID

Affiliation:

1. Northeastern University

2. Boston Children’s Hospital

Abstract

Compound prism arrays are a powerful, yet underutilized, solution for producing high transmission and customized chromatic dispersion profiles over broad bandwidths, the quality of which is unobtainable with commercially available prisms or diffraction gratings. However, the computational complexity associated with designing these prism arrays presents a barrier to the widespread adoption of their use. Here we introduce customizable prism designer software that facilitates high-speed optimization of compound arrays guided by target specifications for chromatic dispersion linearity and detector geometry. Information theory is utilized such that target parameters can be easily modified through user input to efficiently simulate a broad range of possible prism array designs. We demonstrate the capabilities of the designer software to simulate new prism array designs for multiplexed, hyperspectral microscopy that achieve chromatic dispersion linearity and a 70-90% light transmission over a significant portion of the visible wavelength range (500–820 nm). The designer software is applicable to many optical spectroscopy and spectral microscopy applications—with varying requirements for spectral resolution, light ray deviation, and physical size—that are photon-starved and for which the enhanced transmission of refraction versus diffraction warrants custom optical designs.

Funder

Northeastern University

National Institutes of Health

Chan Zuckerberg Initiative

Silicon Valley Community Foundation

Publisher

Optica Publishing Group

Subject

Atomic and Molecular Physics, and Optics

Reference18 articles.

1. Compound prism design principles, I

2. Compound prism design principles, II: triplet and Janssen prisms

3. Compound prism design principles, III: linear-in-wavenumber and optical coherence tomography prisms

4. Northeastern University , “ Compound Prism Designer ,” GitHub ( 2022 ) [accessed 23 Feb 2023], https://github.com/jdtatz/compound-prism-designer .

5. A Mathematical Theory of Communication

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