Abstract
High-toxicity secondary metabolites called aflatoxin are naturally
produced by the fungus Aspergillus. In a warm, humid
climate, Aspergillus growth can be considerably
accelerated. The most dangerous chemical among all aflatoxins is
aflatoxin B1 (AFB1), which has the potential to cause cancer and
several other health risks. As a result, food forensicists now
urgently need a method that is more precise, quick, and practical for
aflatoxin testing. The current study focuses on the development of a
highly sensitive, specific, label-free, and rapid detection method for
AFB1 using a novel humanoid-shaped fiber optic WaveFlex biosensor
(refers to a plasmon wave-based fiber biosensor). The fiber probe has
been functionalized with nanomaterials (gold nanoparticles, graphene
oxide and multiwalled carbon nanotubes) and anti-AFB1 antibodies to
enhance the sensitivity and specificity of the developed sensor. The
findings demonstrate that the developed sensor exhibits a remarkable
low detection limit of 34.5 nM and exceptional specificity
towards AFB1. Furthermore, the sensor demonstrated exceptional
characteristics such as high stability, selectivity, reproducibility,
and reusability. These essential factors highlight the significant
potential of the proposed WaveFlex biosensor for the accurate
detection of AFB1 in diverse agricultural and food samples.
Funder
Natural Science Foundation of Shandong
Province
Liaocheng University
Double-Hundred Talent Plan of Shandong
Province, China
Special Construction Project Fund for
Shandong Province Taishan Mountain Scholars
Subject
Atomic and Molecular Physics, and Optics,Biotechnology
Cited by
3 articles.
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