Polarization-resolved Second Harmonic Generation quantification of the uterine cervix remodeling process

Abstract

We have utilized Polarization Resolved Second Harmonic Generation to image the remodeling uterine cervix in a murine model. We have developed a fully automatic and unbiased process to quantify collagen remodeling at the pixel level (420 nm). We observe a distinct change in collagen fiber arrangement between days 12 and 15 of pregnancy.