Affiliation:
1. Dalian University of Technology
2. University of California Davis Eye Center
3. The Hong Kong Polytechnic University
4. University of California Davis
Abstract
Glaucoma is a group of eye diseases characterized by the thinning of the retinal nerve fiber layer (RNFL), which is primarily caused by the progressive death of retinal ganglion cells (RGCs). Precise monitoring of these changes at a cellular resolution in living eyes is significant for glaucoma research. In this study, we aimed to assess the effectiveness of temporal speckle averaging optical coherence tomography (TSA-OCT) and dynamic OCT (dOCT) in examining the static and potential dynamic properties of RGCs and RNFL in living mouse eyes. We evaluated parameters such as RNFL thickness and possible dynamics, as well as compared the ganglion cell layer (GCL) soma density obtained from in vivo OCT, fluorescence scanning laser ophthalmoscopy (SLO), and ex vivo histology.
Funder
BrightFocus Foundation
National Science Foundation
National Eye Institute
National Natural Science Foundation of China
Dalian University of Technology
Subject
Atomic and Molecular Physics, and Optics,Biotechnology