An implemented fluorescence imaging system for real-time monitoring of colorectal cancer location

Abstract

We report a method for real-time monitoring of colorectal cancer, lymph node metastasis, and tumor growth inhibition of colorectal cancer cells through photodynamic therapy (PDT) using a near-infrared fluorescence diagnostic therapeutic system and fucoidan-based therapeutics. In vitro and in vivo experiments were performed to confirm the effectiveness of the manufactured system and the developed CFN-gel, which has good accumulation efficiency in cancer cells. For comparison of the fabricated CFN-gels, commercial chlorine e6 (Ce6) and 5-aminolevulinic acid (5-ALA) were used. The effectiveness of cancer diagnosis and treatment was confirmed through fluorescence imaging and PDT experiments.